阜阳市耐药结核病患者治疗的福音—新药普托马尼在阜阳市二院成功应用
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background-image: url('https://pic.app.fy169.net/FnEQCfdb6FAHO3fSpkHCzIccCrFS'); visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 2em; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: center; align-items: center; width: 677px; visibility: visible;"><section style="margin: 0px; padding: 0px 8px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; align-items: center; flex-direction: column; width: 677px; visibility: visible;"><section style="margin: 0px; padding: 12px 7px 18px 15px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 661px; text-align: left; background: #ffffff; visibility: visible; border: 1px solid #df8567;"><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">2025年7月19日，阜阳市耐药结核病治疗迎来标志性进展，阜阳市第二人民医院成功为一名耐药结核病患者启用全新抗结核药物普托马尼（Pretomanid），这是该药物在阜阳市的首次临床应用，标志着该市在应对耐药结核病方面拥有了更先进的治疗利器。</span></section><section style="line-height: 1em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;"> </span></section><section style="text-align: center;"><img class="rich_pages wxw-img" src="https://pic.app.fy169.net/FrrYMA8Es2vB23KlWhAy6778mOK8" /></section><section style="line-height: 1em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;"> </span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">在短时间内引进普托马尼新药，对于耐药结核病患者和结核病防治工作具有深远意义。耐药结核病是全球重大公共卫生威胁，传统治疗周期长（18-24个月）、药物不良反应多、治疗费用高且成功率有限，患者常深陷疾病与经济双重困境，甚至被迫中断治疗，加剧疾病传播风险。新药普托马尼的出现，正是击破这一恶性循环的关键一步。</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">普托马尼非普通药物，其独特价值在于：</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">1、攻坚耐药堡垒： 专门对抗传统一线、二线药物均失效的广泛耐药结核（XDR-TB）及复杂耐多药结核（MDR-TB）。</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">2、联合治疗可将疗程缩短6月： 作为BPaL等方案关键成分，可将原本需18个月以上的长程治疗方案，高效缩短至6月左右，治愈率也将从过去的50%提升至90%以上。</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">3、口服便利性： 避免了注射用药的创伤，显著提升治疗依从性和生活质量。</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">普托马尼的成功应用，不仅是技术的突破，更是本市提升公共卫生服务能力、践行“生命至上”理念的切实体现。随着普托马尼在阜阳市二院的成功应用，它不仅为本地患者带来更高效、更耐受的治疗选择，也为构建更强大的区域结核病防控网络注入核心动力。每一次新药的规范使用，都是向终结结核病流行的目标迈出的坚实一步，让“自由呼吸”的权利离每一位市民更近。</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">结核病科简介：</span></section><section style="line-height: 1.75em; text-indent: 2em; text-align: justify;"><span style="font-size: 16px;">阜阳市第二人民医院为阜阳市三区普通结核病和阜阳市耐药结核病定点医院。结核病科收治各种疑难、危重症结核病患者，尤其对于支气管结核、肺外结核、耐药结核病的诊治具有较高的诊疗和管理水平。常规开展结核分子快速检测技术、电子支气管镜技术以及按照三四级手术管理的呼吸内镜诊疗技术，如超声支气管镜、内科胸腔镜、硬质气管镜检查术、气道支架植入术、气道肿瘤消融术、气道瘘封堵术等。呼吸介入+快速分子检测技术很好地应用于结核病患者的诊断和治疗，结合全口服短程新药如普托马尼、贝达喹啉、康替唑胺和德拉马尼的引进，提高耐多药结核病患者的治愈率。依托长三角疑难结核病例定期讨论平台、本院先进的结核病信息化管理系统和阜阳市较好的耐药结核病医疗保障政策，极大提升了本市耐药结核病的综合诊治能力和服务管理水平。</span></section></section><section style="margin: -24.1px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; width: 58px; height: 31px; display: flex; justify-content: center; align-items: center; align-self: flex-end; text-align: justify; text-indent: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 2em;"></section><section style="margin: -24.1px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 58px; height: 31px; display: flex; justify-content: center; align-items: center; align-self: flex-end;"></section><section style="margin: -24.1px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 58px; height: 31px; display: flex; justify-content: center; align-items: center; align-self: flex-end;"></section><section style="margin: -24.1px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 58px; height: 31px; display: flex; justify-content: center; align-items: center; align-self: flex-end;"></section></section></section></section></section><section style="margin: 8px 8px 10px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: #3e3e3e; font-family: inherit; font-size: 24px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: 0.544px; orphans: 2; text-align: center; text-indent: 0px; text-transform: none; white-space: normal; widows: 1; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-style: initial; text-decoration-color: initial; line-height: 25.59px; word-break: normal !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: #222222; letter-spacing: 0.544px; white-space: normal; font-family: 微软雅黑; font-size: 16px; background-color: #ffffff;"><section style="margin: 0px; padding: 0px 4px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.8; letter-spacing: 1px;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; white-space: normal; letter-spacing: 0.544px; widows: 1; font-family: 微软雅黑; background-color: #ffffff;"><section style="margin: 10px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; color: #605af5;"><p style="-webkit-tap-highlight-color: transparent; margin-bottom: 0px; outline: 0px; color: #605af5; font-family: 微软雅黑; font-size: 14px; letter-spacing: 0.544px; text-indent: 0em; widows: 1; background-color: #ffffff; text-align: left; line-height: 2em;"><span style="-webkit-tap-highlight-color: transparent; outline: 0px; font-family: Futura-Medium; color: #888888;">供 稿: 结核科 王志雷</span></p><p style="-webkit-tap-highlight-color: transparent; margin-bottom: 0px; outline: 0px; color: #605af5; font-family: 微软雅黑; font-size: 14px; letter-spacing: 0.544px; text-indent: 0em; widows: 1; background-color: #ffffff; text-align: left; line-height: 2em;"><span style="-webkit-tap-highlight-color: transparent; outline: 0px; font-family: Futura-Medium; color: #888888;">编 辑: 赵上静</span></p><p style="-webkit-tap-highlight-color: transparent; outline: 0px;"> </p><p style="-webkit-tap-highlight-color: transparent; margin-bottom: 0px; outline: 0px; color: #605af5; font-family: 微软雅黑; font-size: 14px; letter-spacing: 0.544px; text-indent: 0em; widows: 1; background-color: #ffffff; text-align: left; line-height: 2em;"><span style="-webkit-tap-highlight-color: transparent; outline: 0px; font-family: Futura-Medium; color: #888888;">责任编辑: 马晓琳</span></p><p style="-webkit-tap-highlight-color: transparent; outline: 0px;"> </p><p style="-webkit-tap-highlight-color: transparent; margin-bottom: 0px; outline: 0px; color: #605af5; font-family: 微软雅黑; font-size: 14px; letter-spacing: 0.544px; 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